Developmental biology

Hemojuvelin deficiency in zebrafish0

Hemojuvelin deficiency in zebrafish

Hemojuvelin (Hjv) is a member of the repulsive-guidance molecule (RGM) family that upregulates transcription of the iron regulatory hormone hepcidin by activating the bone morphogenetic protein (BMP) signaling pathway in mammalian cells. Hepcidin has been called the master regulator for iron, and hepcidin expression and regulation deviations have been implicated in disease such as juvenile hemochromatosis and thalassemia. This paper evaluates the effects of hjv on hepcidin expression in embryonic zebrafish development.

Analysis of the role of Bhlhb5 and Prdm8 in neural development0

Analysis of the role of Bhlhb5 and Prdm8 in neural development

Stephanie I. Mok Harvard College ‘09, moksi@mail.nih.gov In neural development, Bhlhb5 and Prdm8 may have a cooperative role in the same regulatory processes underlying neuronal differentiation and maturation. Three potential models of interaction are proposed. The three models are: 1) Bhlhb5 and Prdm8 regulate the same target genes, but do not bind together in complex, 2) Bhlhb5 and Prdm8 interact [...]