Research

A Braille tale

The blind in China face the difficult challenge of learning to read Chinese. The current Braille system has a number of shortcomings, causing several communication problems between the blind and the sighted. A proposed system based on the Japanese Braille system could help the blind better their opportunities and way of life.

Price differentials among hospitals in Massachusetts

Health care in Massachusetts ranks exceptionally well but suffers from high hospital costs. This study examines why prices for similar services vary so much among Massachusetts hospitals.

Spatial organization of neocortical myelinated axons at the ultrastructural level

This paper examines the organization of myelinated axons, the long neuronal processes integral to long distance communication in the brain circuitry.

Hill stability and Kozai evolution with applications to Kuiper belt binaries

This study investigates the stability of a three-body system, which is a difficult problem in astrophysics. The author focuses on how stability criteria are altered when considering the Kozai effect, or the periodic alternation of inclination and eccentricity in the smaller binary pair.

Evolving 2-CNF under uniform distribution

This paper extends the model of Darwinian evolution through computational learning, showing that the class of 2-CNF functions are evolvable when input variables are uniformly distributed.

Price theory and the U.S. Congress

This paper aims to determine whether discrimination theory or human capital theory better explains the historical underrepresentation of women in Congress.

Hemojuvelin deficiency in zebrafish

Hemojuvelin (Hjv) is a member of the repulsive-guidance molecule (RGM) family that upregulates transcription of the iron regulatory hormone hepcidin by activating the bone morphogenetic protein (BMP) signaling pathway in mammalian cells. Hepcidin has been called the master regulator for iron, and hepcidin expression and regulation deviations have been implicated in disease such as juvenile hemochromatosis and thalassemia. This paper evaluates the effects of hjv on hepcidin expression in embryonic zebrafish development.

The NBA soft cap and luxury tax

This paper evaluates the impact of the National Basketball Association (NBA)’s soft salary cap and luxury tax system, and showed that talent and payroll are linked within the league, causing unbalanced team competitiveness.

Methods of detecting tacit collusion in FCC spectrum auctions

An analysis of methods for detecting tacit collusion in FCC spectrum auctions.

Probing the nuclear role of Ube3a in the pathogenesis of Angelman syndrome

Angelman syndrome (AS) is a severe neurological disorder often involving epilepsy, autistic tendencies, mental retardation and ataxia. The genetic locus of the disorder has been identified as an inability to inherit a functional maternal copy of the gene UBE3A, which encodes for a ubiquitin ligase involved in proteasome-mediated degradation. Here, Zapf and Anderson characterizes the effect of Ube3a on tissue development.