Hemojuvelin (Hjv) is a member of the repulsive-guidance molecule (RGM) family that upregulates transcription of the iron regulatory hormone hepcidin by activating the bone morphogenetic protein (BMP) signaling pathway in mammalian cells. Hepcidin has been called the master regulator for iron, and hepcidin expression and regulation deviations have been implicated in disease such as juvenile hemochromatosis and thalassemia. This paper evaluates the effects of hjv on hepcidin expression in embryonic zebrafish development.
This paper evaluates the impact of the National Basketball Association (NBA)’s soft salary cap and luxury tax system, and showed that talent and payroll are linked within the league, causing unbalanced team competitiveness.
An analysis of methods for detecting tacit collusion in FCC spectrum auctions.
Angelman syndrome (AS) is a severe neurological disorder often involving epilepsy, autistic tendencies, mental retardation and ataxia. The genetic locus of the disorder has been identified as an inability to inherit a functional maternal copy of the gene UBE3A, which encodes for a ubiquitin ligase involved in proteasome-mediated degradation. Here, Zapf and Anderson characterizes the effect of Ube3a on tissue development.
Despite India’s longstanding efforts to combat Iodine Deficiency Disorders through a Universal Salt Iodization program, only 51% of households were using iodized salt in 2005. In order to justify efforts to actively expand the program, it is crucial to establish a causal link between access to iodized salt and child health. This study examined household salt iodine concentration, anthropometric outcomes, and birth histories of over 18,000 children from the 1998 India National Family Health Survey.
In this paper, we study the magnitude of coattail effects in the 2008 election, or the impact of the presidential election on congressional elections. We utilize data from electronic prediction markets to measure these effects.
The CCR5-∆32 deletion mutation is a naturally-occurring genetic polymorphism that confers strong resistance to HIV-1 infection. I propose the use of chimeric recombinase enzymes as a gene therapy method to safely emulate the natural mutation in CCR5 and therefore confer resistance to HIV-1.
While olfactory receptor neurons’ pre-synaptic activity have been extensively researched in anesthetized mice, little is known about odor-evoked synaptic activity in awake, freely moving animals. This project attempts to address this problem by adapting a fiber optic bundle imaging technique to the olfactory bulb.
This paper analyzes scapegoatism from the perspective of the individual members of a social network, their social utilities, and the decisions that result. Using basic psychological descriptions of the effects of a scapegoat event on the members of a social group, this paper formalizes an economic model to describe this dynamic social process. Furthermore, the model’s results lead to several general conclusions about the factors that increase the likelihood of scapegoat events.
The silk macromolecule fibroin is used in biomedicine in the silk I and II conformations, which have well characterized structures and properties. It was hypothesized that the fibroin crystalline structure silk III could have similar properties. This research assessed key properties of silk III fibroin to facilitate future manufacture and biomedical applications.
